World`s 1st Genomic Nutricart - Where Science Meets Nourishment
Diabetes
Diabetes type 2, is a complex disease with a dynamic interplay between genetics and environmental factors, upregulating the expression of various genes that could potentially hamper insulin sensitivity. The heritability of type 2 diabetes is estimated to be in the range of 25% to 72% based on family and twin studies. The above image represents a snapshot of the output from a Genetic test that underscores the importance of underlying gene markers that could alter the levels of LDL, HDL, and triglycerides, resulting in Diabetes and Cardiovascular conditions. Some of the most prominent genes involved in the etiology of diabetes are as follows:
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CETP Gene – Variations on this gene associated with higher CETP activity, can lower HDL levels and increase triglyceride levels in the blood.
LDL
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LDLR Gene – Mutations can alter the levels of LDLR, thereby resulting in FH. Consequently, the risk of atherosclerosis rises.
Triglycerides
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KCNJ11 – Variations on this gene impairs insulin release [1].
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PPARG – Specific Variation on this gene has a protective effect as it improves insulin sensitivity. Therefore, candidates with this variation could circumvent the possibility of contracting diabetes with the right Diet intervention [2].
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TCF7L2 – Variations on this gene impairs insulin secretion and glucose homeostasis [3].
References
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Haghvirdizadeh P, et al. KCNJ11: Genetic polymorphisms and risk of Diabetes Mellitus. Journal of Diabetes research. 2015. DOI: https://pubmed.ncbi.nlm.nih.gov/26448950/.
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Altshuler, D, et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics. 2000, 26:1.
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Bosque-Plata L, et al. The role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021, 70:6. DOI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275893/.