World`s 1st Genomic Nutricart - Where Science Meets Nourishment
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Genetic Variations play a crucial role in the pathophysiology of Cardiovascular conditions. Many forms of CVD, such as coronary artery disease (CAD) and hypertension, are influenced by multiple genes, each contributing a small amount to the overall risk. Polygenic risk scores, aggregate the combined effects of multiple gene variants that can help predict an individual's susceptibility to these conditions. Some of the well-studied genes involved in the Cardiovascular dynamics are as follows:
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ADRB2 - The genetic variations associated with this gene influences Venous Blood Flow. Mutations can cause dysfunctional beta-2 adrenergic receptors (ADBR2) that impairs vasodilation, resulting in reduced blood flow and increased risk of clot formation.
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APOA4 - Apolipoprotein A-IV has anti-inflammatory properties. Variations on the APOA4 gene can potentially downregulate the anti-inflammatory properties of this gene, resulting in increased oxidative stress, contributing to Coronary Artery Disease.
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CELSR2 - Genetic variants associated with the CELSR2 gene lead to higher LDL cholesterol levels can promote the development of atherosclerosis. This condition involves the buildup of fatty deposits in the arterial walls, narrowing the arteries and restricting blood flow to the heart.